tadalafil tadalista 20mg is a medicine that helps men with erectile dysfunction by increasing blood flow to their penis. The drug works by inhibiting the action of PDE-5 hormones in the body. It also increases the levels of nitric oxide in the blood. Before using this medication, you should talk with your doctor about your medical history and any other medications you are taking. You should also tell your doctor if you have any heart disease or other conditions that affect the heart. These conditions can put extra strain on your heart and increase your risk of developing side effects from this medication.